Safety And Tolerability Of Cannabidiol In Parkinson Disease in Elgin-Illinois thumbnail

Safety And Tolerability Of Cannabidiol In Parkinson Disease in Elgin-Illinois

Published Jan 09, 23
4 min read

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A number of small studies and anecdotal evidence suggests that cannabidiol (CBD) oil for Parkinson’s may help with some symptoms. However, there is no conclusive research showing CBDs effectiveness in treating Parkinson’s or its symptoms.The Parkinson’s Foundation issued a Consensus Statement on the Use of Medical Cannabis for Parkinson’s Disease in 2020.

The statement urges caution, pointing to potential side effects, and emphasizes the need for more research. That said, as of yet, the Food and Drug Administration has only approved one CBD-based drug for the treatment of a rare seizure disorder. This approval has increased interest in the use of CBD in the treatment of movement disorders, such as Parkinson’s.

A number of studies suggest that there may be some benefits of CBD for Parkinson’s. The problem is that most of these studies are small, low quality, or animal studies rather than human ones. Additionally, because the FDA does not regulate CBD products, there is no guarantee that product purity is consistent, making it difficult to get the right dose.

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More research needs to test this claim. A 2020 study tested Epidiolex, an FDA-approved CBD drug for seizures, for Parkinson’s. Of 13 participants, three quit the study because of side effects. The remaining 10 experienced improvements in their Parkinson’s disease symptoms. However, five of 13 participants developed elevated liver enzymes — a side effect the researchers attribute to the high dose of the drug.

A 2019 paper reviewed prior studies on CBD and Parkinson’s. The study included four randomized controlled trials. However, just one of these trials showed improvements in Parkinson’s symptoms among participants. In seven preclinical models of Parkinson’s disease, six studies suggested CBD could offer neuroprotective benefits. In three additional trials of CBD and Parkinson’s — one randomized controlled trial, one case series, and one open-label study — participants tolerated CBD well.

Non-motor symptoms can be more difficult to treat with standard Parkinson’s treatment. Once again, however, these studies involved only small groups of participants and were short in length. The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.

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However, CBD products containing more than 0. 3 percent THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled.

Studies of CBD often use dosages of per day. People who want to try CBD should start with a low dosage, then gradually increase the dosage only if they experience no side effects. Before trying CBD, contact a doctor about the risks and benefits, as well as any potential drug interactions.

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that the FDA does not rigorously test CBD products to ensure they work. Some potential risks include: liver injury, especially if a person uses large quantities of CBDinjuries from other ingredients in CBD productsdrug interactionsallergic reactions drowsiness that can make driving dangerousanxiety and panicdisturbed sleep agitation and irritabilitystomach issues such as nausea and diarrhea, Some animal studies suggest CBD may affect male reproductive health.

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They also do not know the long-term effects of CBD use. Parkinson’s is a progressive, degenerative medical condition with no cure. This means that even with treatment, symptoms tend to get worse with time. The lack of a cure and the both help explain why some people with the disease try CBD.

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A doctor may also prescribe drugs such as: carbidopa to ease drug side effectspramipexole or ropinirole in younger people amantadineanticholinergic drugs Parkinson’s drugs usually ease symptoms for 3 to 6 years. However, they become less effective after that period. A person may also need additional medications to manage symptoms such as erectile dysfunction, fatigue, depression, or mood changes.

They include physical therapy to preserve physical strength, psychotherapy to deal with the challenges of living with Parkinson’s, assistive devices, and accommodations at work and school. Cannabis usually refers to products containing tetrahydrocannabinol (THC), which is the psychoactive compound found in cannabis. Studies on using cannabis to treat Parkinson’s experience similar shortcomings as studies on using CBD oil as treatment.

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About half of the participants were aware of medical cannabis options in Germany (where it is legal) and 8. 2% reported using it. Additionally, 68% reported using THC products. Participants generally reported improvement in symptoms, including: reductions in pain and muscle crampsreductions in tremorsreductions in anxiety and depression, Participants also reported that cannabis had few side effects.